Creon 10000 Dosage/Direction for Use

The posology aims at individual needs and depends on the severity of the disease and the composition of food. It is recommended to take the enzymes during or immediately after the meals.
The capsules should be swallowed intact, without crushing or chewing, with enough fluid during meals or snacks.
When swallowing of capsules is difficult (e.g. small children or elderly patients), the capsules may be carefully opened and the pellets added to acidic soft food [pH <5.5] that does not require chewing, or the pellets will be taken with acidic liquid with [pH <5.5]. This could be apple sauce or yogurt or fruit juice with a pH less than 5.5, e.g. apple, orange or pineapple juice. This mixture should not be stored. Crushing and chewing of the pellets or mixing with food or fluid with a pH greater than 5.5 can disrupt the protective enteric coating. This can result in early release of enzymes in the oral cavity and may lead to reduced efficacy and irritation of the mucous membranes.
Care should be taken that no product is retained in the mouth.
It is important to ensure adequate hydration at all times, especially during periods of increased loss of fluids. Inadequate hydration may aggravate constipation. Any mixture of the pellets with food or liquids should be used immediately and should not be stored.
Dosing in pediatric and adult patients with cystic fibrosis: Based upon a recommendation of the Cystic Fibrosis Consensus Conference, the US CF Foundation case-control study, and the UK case-control study, the following general dosage recommendation for pancreatic enzyme replacement therapy can be proposed: Weight-based enzyme dosing should begin with 1 000 lipase units/kg/meal for children less than four years of age and with 500 lipase units/kg/meal for those over age four.
Dosage should be adjusted according to the severity of the disease, control of steatorrhea and maintenance of good nutritional status.
Most patients should remain below or should not exceed 10 000 lipase units/kg body weight per day or 4000 lipase units/gram fat intake.
Dosing in other condition associated with exocrine pancreatic insufficiency: Dosage should be individualized by patient according to the degree of maldigestion and the fat content of the meal. The required dose for a meal ranges from about 25 000 to 80 000 Ph. Eur. units of lipase and half of the individual dose for snacks.
Dose of 1 to 2 capsules of Creon 10,000 per meal for the improvement of digestion and relief of maldigestion symptoms after consumption of a (fatty) meal (Refer to Indications/Uses).